Work

Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins

Year: 2008

Type: article

Abstract: From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00452-08

Authors: Guangshun Wang, Karen M. Watson, Robert W. Buckheit

Institutions: Nebraska Medical Center, University of Nebraska Medical Center, ImQuest BioSciences (United States)

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2127536099

FWCI: 4.799

Cites: 41

Cited by: 116

Related to: 10