Work

Emerging Importance of Mutational Analysis in Myelodysplastic Syndrome and Acute Myelogenous Leukemia

Year: 2013

Type: review

Abstract: In 1956, the diploid number of chromosomes in humans was established as 46, opening the door for cytogeneticists to identify numerical and structural chromosome abnormalities that lead to human disease. Nearly 6 decades of critical discoveries describing the genetic underpinnings of leukemia have followed this watershed moment and provided drugable targets, including the Philadelphia chromosome, PML-RARA, and FLT3. The management of myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) relies on cytogenetic analysis, because karyotype is a robust and independent predictor of outcome.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.010

Authors: Aaron T. Gerds, Matthew J. Walter, Bart L. Scott

Institutions: University of Washington, Fred Hutch Cancer Center, Washington University in St. Louis

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650