Controlled Release Drug Coatings on Flexible Neural Probes
Year: 2007
Type: conference-paper
Abstract: We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biodegradable polymer. The drug eluting coating is applied to flexible polymer neural probes with platinum electrodes. The drug eluting device is implanted in one hemisphere of a rat, while a control device is implanted in the opposite hemisphere. Impedance measurements are performed to determine the effect of the drug eluting coating on the tissue reaction surrounding the probe and the electrical characteristics of the devices. Probes that are coated with drug eluting coatings show better long term impedance characteristics over control probes. These coatings can be used to increase the reliability and long term success of neural prostheses.
Source: Conference proceedings
Authors: Andre Mercanzini, Sai Reddy, Diana Velluto, Philippe Colin, Anne Maillard, Jean-Charles Bensadoun, Arnaud Bertsch, Jeffrey A. Hubbell, Philippe Renaud
Institution: École Polytechnique Fédérale de Lausanne
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2127679909