Work

Mechanisms MediatingPorphyromonas gingivalisGingipain RgpA-Induced Oral Mucosa Inflammation In Vivo

Year: 2001

Type: article

Abstract: Suffusion of gingipain RgpA (GRgpA) elicited a significant concentration-dependent increase in the clearance of macromolecules from in situ hamster cheek pouch which was attenuated by NPC 17647, a selective bradykinin B(2) receptor antagonist. Leupeptin and a mixture of proteinase inhibitors also attenuated GRgpA-induced responses. These data indicate that GRgpA elicits plasma exudation from in situ oral mucosa in a catalytic site-dependent fashion by elaborating bradykinin.

Source: Infection and Immunity

DOI: 10.1128/iai.69.2.1199-1201.2001

Authors: Israel Rubinstein, Jan Potempa, James Travis, Xiao-Pei Gao

Institutions: University of Illinois Chicago, University of Georgia

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Dental and Craniofacial Research