Work

Reduced Hippocampal Activity in Youth with Posttraumatic Stress Symptoms: An fMRI Study

Year: 2009

Type: article

Abstract: OBJECTIVE: Youth who experience interpersonal trauma and have posttraumatic stress symptoms (PTSS) develop cognitive deficits that impact their development. Our goal is to investigate the function of the hippocampus in adolescents with PTSS during a memory processing task. METHODS: Twenty-seven adolescents between the ages of 10-17 years (16 with PTSS and 11 healthy controls) encoded and retrieved visually presented nouns (Verbal Declarative Memory Task) while undergoing fMRI scanning. RESULTS: The PTSS group demonstrated reduced activation of the right hippocampus during the retrieval component of the task. Further, severity of symptoms of avoidance and numbing correlated with reduced left hippocampal activation during retrieval. CONCLUSIONS: Decreased activity of the hippocampus during a verbal memory task may be a neurofunctional marker of PTSS in youth with history of interpersonal trauma. The results of this study may facilitate the development of focused treatments and may be of utility when assessing treatment outcome for PTSS.

Source: Journal of Pediatric Psychology

DOI: 10.1093/jpepsy/jsp112

Authors: V. G. Carrion, B. W. Haas, A. Garrett, S. Song, A. L. Reiss

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Posttraumatic Stress Disorder Research

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Foundation for Suicide Prevention, National Alliance for Research on Schizophrenia and Depression, National Institutes of Health, National Institute of Mental Health