Work

Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations

Year: 2011

Type: article

Abstract: Eukaryotic genomes possess an elaborate and dynamic higher-order structure within the limiting confines of the cell nucleus. Knowledge of the physical principles and the molecular machinery that govern the 3D organization of this structure and its regulation are key to understanding the relationship between genome structure and function. Elegant microscopy and chromosome conformation capture techniques supported by analysis based on polymer models are important steps in this direction. Here, we review results from these efforts and provide some additional insights that elucidate the relationship between structure and function at different hierarchical levels of genome organization.

Source: BMC Biophysics

DOI: 10.1186/2046-1682-4-8

Authors: Balaji VS Iyer, Martin Kenward, Gaurav Arya

Institution: University of California San Diego

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,170

Funders: Directorate for Biological Sciences, University of California, San Diego