Work

Distal Convoluted Tubule

Year: 2014

Type: review

Abstract: The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.

Source: Clinical Journal of the American Society of Nephrology

DOI: 10.2215/cjn.05920613

Authors: Arohan R. Subramanya, David H. Ellison

Institutions: University of Pittsburgh, VA Pittsburgh Healthcare System, Oregon Health & Science University, Portland VA Medical Center

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases