Work

Membrane organization and tumorigenesis—the NF2 tumor suppressor, Merlin

Year: 2005

Type: preprint

Abstract: The NF2 tumor-suppressor gene was cloned more than a decade ago, but the function of its encoded protein, Merlin, remains elusive. Merlin, like the closely related ERM proteins, appears to provide regulated linkage between membrane-associated proteins and the actin cytoskeleton and is therefore poised to function in receiving and interpreting signals from the extracellular milieu. Recent studies suggest that Merlin may coordinate the processes of growth-factor receptor signaling and cell adhesion. Varying use of this organizing activity by different types of cells could provide an explanation for the unique spectrum of tumors associated with NF2 deficiency in mammals.

Source: Genes & Development

DOI: 10.1101/gad.1335605

Authors: Andrea I. McClatchey, Marco Giovannini

Institutions: Harvard University, Inserm, Fondation Jean Dausset-CEPH, Massachusetts General Hospital, Institut Universitaire d'Hématologie

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze