Cerebellar Brain-Derived Neurotrophic Factor–TrkB Defect Associated with Impairment of Eyeblink Conditioning inStargazerMutant Mice
Year: 1998
Type: article
Abstract: In the spontaneous ataxic mutant mouse stargazer, there is a selective reduction of brain-derived neurotrophic factor (BDNF) mRNA expression in the cerebellum. BDNF protein levels in the cerebellum are reduced by 70%. Despite normal levels of full-length and truncated TrkB receptor, constitutive and neurotrophin-4/5-induced tyrosine phosphorylation was significantly reduced in several signal transduction molecules, including phospholipase-Cgamma1, erk1, and erk2. Morphological examination revealed an increased number of external granule cells at postnatal day 15 and the presence of abnormal neurons resembling immature granule cells in the adult. These abnormalities are associated with a severe impairment in the acquisition of classical eyeblink conditioning, indicating cerebellar malfunction. Our data suggest that normal BDNF expression and TrkB signal transduction in the cerebellum are necessary for learning and plasticity in this model.
Source: Journal of Neuroscience
Authors: Xiaoxi Qiao, Lu Chen, Hua Gao, Shaowen Bao, Franz Hefti, Richard F. Thompson, Beat Knusel
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Awards: PHARMACOLOGY OF NGF FOR FOREBRAIN CHOLINERGIC NEURONS, THERAPEUTIC POTENTIAL OF NEUROTROPHINS IN ALZHEIMERS, G2491065565, G3162978704, G3171254544, G3226863924, DOPAMINERGIC AND BASAL GANGLIA PLASTICITY IN AGING, G5116978657, Neurobiological Analysis of Plasticity: Learning and Memory, Alzheimer Disease Research Center, G8876996369, G9000064772
OpenAlex ID: W2128120086