Work

Silica nanoparticle-generated ROS as a predictor of cellular toxicity: mechanistic insights and safety by design

Year: 2015

Type: article

Abstract: studies correlate well and implicate production of ROS from a surface-catalyzed reaction as a predictor of cellular toxicity. The data demonstrate that mesoporous materials are intrinsically less toxic than nonporous materials, and that surface functionalization can mitigate toxicity in nonporous materials by reducing free radical production. The broader implications are in terms of safety by design of nanomaterials, which can only be extracted by mechanistic studies such as the ones reported here.

Source: Environmental Science Nano

DOI: 10.1039/c5en00179j

Authors: Sean E. Lehman, Angie S. Morris, Paul S. Mueller, Aliasger K. Salem, Vicki H. Grassian, Sarah C. Larsen

Institution: University of Iowa

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research