Aptamer‐Crosslinked Microbubbles: Smart Contrast Agents for Thrombin‐Activated Ultrasound Imaging
Year: 2012
Type: article
Abstract: Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.
Source: Advanced Materials
Authors: Matthew A. Nakatsuka, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha, Andrew P. Goodwin
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G2881053379, Center of Nanotechnology for Treatment, Understanding, *, Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for, Stimulus-Responsive Microbubbles for Site-Specific Imaging of Thrombosis, In Vivo Cellular and Molecular Imaging Centers (ICMICs), Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents , UCSD Cancer Center Training Program in Drug Development
OpenAlex ID: W2128217496