Dietary Intake of Vitamin D and Calcium and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition
Year: 2013
Type: article
Study design: Observational Study
Abstract: Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre- and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (P(trend) = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (P(interaction) = 0.57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
Source: Nutrition and Cancer
Authors: Sascha Abbas, Jakob Linseisen, Sabine Rohrmann, Jenny Chang-Claude, Petra H Peeters, Pierre Engel, Magritt Brustad, Eiliv Lund, Guri Skeie, Anja Olsen, Anne Tjønneland, Kim Overvad, Marie-Christine Boutron-Ruault, Francoise Clavel-Chapelon, Guy Fagherazzi, Rudolf Kaaks, Heiner Boeing, Brian Buijsse, George Adarakis, Vassilis Ouranos, Antonia Trichopoulou, Giovanna Masala, Vittorio Krogh, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, Genevieve Buckland, Marcial Vicente Argüelles Suárez, Maria-José Sánchez, Maria-Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Per Lenner, Malin Sund, H. B. Bueno-de-Mesquita, Fränzel J. B. van Duijnhoven, Kay-Tee Khaw, Nick Wareham, Timothy J. Key, Veronika Fedirko, Isabelle Romieu, Valentina Gallo, Teresa Norat, Petra A Wark, Elio Riboli
Institutions: German Cancer Research Center, University of Cologne, Helmholtz Munich, University of Zurich, Institute of Social and Preventive Medicine, University Medical Center Utrecht, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, UiT The Arctic University of Norway, Danish Cancer Society, Aarhus University, German Institute of Human Nutrition, Hellenic Health Foundation, National and Kapodistrian University of Athens, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, Azienda Usl 8 Arezzo, Italian institute for Genomic Medicine, Piedmont Reference Center for Epidemiology and Cancer Prevention, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Andalusian School of Public Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Biogipuzkoa Health Research Institute, Lund University, Skåne University Hospital, Umeå University, National Institute for Public Health and the Environment, Wageningen University & Research, University of Cambridge, Medical Research Council, University of Oxford, Centre international de recherche sur le cancer, Imperial College London
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2128415251