Work

Nuclear Trafficking of Retroviral RNAs and Gag Proteins during Late Steps of Replication

Year: 2013

Type: review

Abstract: Retroviruses exploit nuclear trafficking machinery at several distinct stages in their replication cycles. In this review, we will focus primarily on nucleocytoplasmic trafficking events that occur after the completion of reverse transcription and proviral integration. First, we will discuss nuclear export of unspliced viral RNA transcripts, which serves two essential roles: as the mRNA template for the translation of viral structural proteins and as the genome for encapsidation into virions. These full-length viral RNAs must overcome the cell's quality control measures to leave the nucleus by co-opting host factors or encoding viral proteins to mediate nuclear export of unspliced viral RNAs. Next, we will summarize the most recent findings on the mechanisms of Gag nuclear trafficking and discuss potential roles for nuclear localization of Gag proteins in retrovirus replication.

Source: Viruses

DOI: 10.3390/v5112767

Authors: Matthew Stake, Darrin Bann, Rebecca Kaddis, Leslie Parent

Institution: Pennsylvania State University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,137

Funders: National Cancer Institute, National Institute of General Medical Sciences