Work

Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine.

Year: 1981

Type: article

Abstract: The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum greater than ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

Source: Gut

DOI: 10.1136/gut.22.1.14

Authors: M Camilleri, B T Cooper, T E Adrian, S R Bloom, V S Chadwick

Institutions: Hammersmith Hospital, Imperial College London

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2128578063