Work

285: Manifestations of acute and chronic graft-versus-host-disease in reduced-intensity allogeneic stem cell transplantation (RISCT) for pediatric cancer

Year: 2007

Type: article

Abstract: Background: Allogeneic stem cell transplantation (alloSCT) plays an important role in the treatment of pediatric malignancies. Unfortunately, its success is limited by toxicities associated with myeloablative preparative regimens. We have piloted a reduced intensity alloSCT (RISCT) approach intended to reduce toxicity and to promote rapid immune recovery and enhanced Graft-Versus-Tumor (GVT) effect. The risk of increased GVT effects may coincide with increased manifestations of GVHD. Although the adult RISCT experience has shown increased GVHD, the pediatric oncology experience is limited.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2006.12.290