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New DNA polymorphisms of human MMHOGG1 gene: Prevalence of one polymorphism among lung‐adenocarcinoma patients in Japanese

Year: 1999

Type: article

Abstract: MMH/OGG1 is an 8-hydroxyguanine-specific DNA glycosylase/AP-lyase, one of the mutator enzymes for the excision repair of 8-hydroxyguanine. DNA polymorphisms in human MMH/OGG1 gene were newly identified and analyzed to examine a possible association with lung-cancer risk by a population-based study. Polymorphic allele 3 in hMMH/OGG1 exon 1 was significantly prevalent among Japanese patients with adenocarcinoma of the lung [odds ratio (OR): 3.152, 95% confidence interval (CI): 1.266-7.845], indicating that the excision repair of 8-hydroxyguanine may play a role in predisposition to lung cancer.

Source: International Journal of Cancer

DOI: 10.1002/(sici)1097-0215(19990105)80:1<18::aid-ijc4>3.0.co;2-e

Authors: Toshimitsu Ishida, Rieko Takashima, Masashi Fukayama, Chikuma Hamada, Yoshitaka Hippo, Takeshi Fujii, Sachiko Moriyama, Chikako Matsuba, Yutaka Nakahori, Hiroyuki Morita, Yoshio Yazaki, Tatsuhiko Kodama, Susumu Nishimura, Hiroyuki Aburatani

Institutions: The University of Tokyo, Jichi Medical University, Jichi Medical University Hospital, Tokyo Metropolitan Komagome Hospital, Research Center for Advanced Science and Technology, The University of Tokyo, Merck Biopharma Co., Ltd. (Japan)

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2128953017

FWCI: 2.49

Cites: 22

Cited by: 70

Related to: 9