Work

Differential Expression of Caprine β-Defensins in Digestive and Respiratory Tissues

Year: 1999

Type: article

Abstract: We identified two novel beta-defensin precursors, preproGBD-1 and preproGBD-2, in the tissues of a goat. Although the precursors were identical in 96.8% of their bases and 88.2% (60 of 68) of their amino acids, preproGBD-1 was expressed principally in the tongue and respiratory tract, whereas preproGBD-2 expression predominated throughout the intestine. These findings exemplify the phenomenon of tissue-specific expression in a family of host defense peptides that arose before the avian and mammalian lineages diverged.

Source: Infection and Immunity

DOI: 10.1128/iai.67.11.6221-6224.1999

Authors: Chengquan Zhao, Tung Nguyen, Lide Liu, Olga Shamova, Kim Brogden, Robert I. Lehrer

Institutions: Institute of Experimental Medicine, Agricultural Research Service, National Animal Disease Center, University of California, Los Angeles

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center

Awards: G1249585958, BETA-DEFENSINS IN THE FEMALE GENITAL TRACT AND KIDNEYS, G3430854323, G4163362259, BIOCHEMISTRY