Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral Therapy
Year: 1999
Type: article
Study design: Case Report
Abstract: In human immunodeficiency virus (HIV)-infected patients treated with potent antiretroviral therapy, the persistence of latently infected cells may reflect the long decay half-life of this cellular reservoir or ongoing viral replication at low levels with continuous replenishment of the population or both. To address these possibilities, sequences encompassing the C2 and V3 domains of HIV-1 env were analyzed from virus present in baseline plasma and from viral isolates obtained after 2 years of suppressive therapy in six patients. The presence of sequence changes consistent with evolution was demonstrated for three subjects and correlated with less complete suppression of viral replication, as indicated by the rapidity of the initial virus load decline or the intermittent reappearance of even low levels of detectable viremia. Together, these results provide evidence for ongoing replication. In the remaining three patients, virus recovered after 2 years of therapy was either genotypically contemporary with or ancestral to virus present in plasma 2 years before, indicating that virus recovery had indeed resulted from activation of latently infected cells.
Source: Journal of Virology
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, U.S. Department of Veterans Affairs, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Center for AIDS Research, University of Washington, Medical Research Council, National Institute of Allergy and Infectious Diseases, National Center for Research Resources
Awards: G2034456173, Teilnahme an der 7. Konferenz in Genf der 'International Society for Nubian Studies'., G2369189099, Genese und landschaftsökologische Aspekte der Terrassenland- schaft des Unterengadins (GR, Schweiz)., Modeling Viral and T Lymphocyte Dynamics, ANTIVIRAL RESISTANCE IN AIDS, ADULT ACTG CENTRAL GROUP, G5489226248, G5816822016, G606870053, G724937252, Total Asymmetric Syntheses of Natural Products and of Compounds Biological Interest, Development of a low power, electrochemical material which will result in a large, rapid change in absorbance of light on appli- cation of a small potential field., G9000015163, G9000027917, San Diego Center for AIDS Research (SD CFAR)
OpenAlex ID: W2129136949