Work

Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells

Year: 2005
Type: article
Abstract: Studies of the human immunodeficiency virus type 1 (HIV-1) continue to enrich eukaryotic biology and immunology. Recent advances have defined factors that function after viral entry and prevent the replication of proviruses in the infected cell. Some of these attack directly viral structures whereas others edit viral genetic material during reverse transcription. Together, they provide strong and immediate intracellular immunity against incoming pathogens. These processes also offer a tantalizing glimpse at basic cellular mechanisms that might restrict the movement of mobile genetic elements and protect the genome.
Language: English
Subfield: Virology
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W2129150715
FWCI: 1.21
Cites: 114
Cited by: 20
Related to: 10