Trends in incidence and prognosis in female breast cancer since 1955 : registry-based studies in south-east Netherlands
Year: 1995
Type: dissertation
Study design: Observational Study
Abstract: Indirect evidence forms the basis of our knowledge of the natural history of human\\nbreast cancer. It is assumed that breast cancer starts by subtle molecular changes\\nwithin a cell, called the induction phase, leading to the creation of a malignant cell.\\nThis phase is followed by multiplication and progressive growth of the cancer cell,\\nmost often leading to disseminated disease and to the death of the patient. \\nFrom clinical observation it can be concluded that the range in growth rates of\\nbreast cancer is wide, and probably also the moment and pattern of metastatic\\ndissemination. Some cancers disseminate early, but others may disseminate late or\\nnot at all. From serial mammographies it appeared that growth rates, expressed as\\ntumour volume doubling times, ranged from about two months to several years." The\\nsite of metastasis is also highly variable, as well as the response to therapy.\\nTogether, this illustrates the heterogeneity of breast cancer.
Author: Henk Nab
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2129162484