Work

Insulin-Induced Hypoglycemia and Its Effect on the Brain

Year: 2011

Type: article

Abstract: Hypoglycemia, a frequent occurrence during mod-ern intensive insulin therapy, remains the majorlimiting factor in achieving optimal glucosecontrol in type 1 diabetic patients as well as in patients with long-standing type 2 diabetes. This has been a challenge for clinicians and investigators since several large population-based studies such as the Diabetes Con-trol and Complications Trial and UK Prospective Diabetes Study established the long-term benefits of tight glycemic control many years ago (1,2). More recently, studies of intensive glucose control in patients with diabetes of sev-eral years duration have—to the surprise to many—been either terminated because of increased mortality in the intensive control arm or because worse outcomes were revealed in regard to the clinical end points (3,4). In a parallel development, we have gone, over the course of 10 years, from embracing stringent inpatient glucose con-trol via insulin infusion protocols in the intensive care set-

Source: Diabetes

DOI: 10.2337/db11-0498

Authors: Raimund I. Herzog, Robert S. Sherwin, Douglas L. Rothman

Institution: Yale University

Language: English

Topic: Diabetes Management and Research

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Diabetes and Digestive and Kidney Diseases