Work

Vibrational Photoacoustic Microscopy for Depth-resolved Bond-selective Imaging of Tissues and Organisms

Year: 2011

Type: conference-paper

Abstract: We realize vibrational photoacoustic microscopy (VPA) using molecular excitation of overtone vibration and acoustic detection of the resultant pressure transients. We demonstrate 3-D VPA imaging of lipid-rich atherosclerotic plaques and lipid bodies in living Drosophila larvae by exciting 2nd overtone of the CH bond stretch around 8300 cm−1. Depth-resolved spectral analysis and a penetration depth of several mm are available.

DOI: 10.1364/cleo_at.2011.jtug3

Authors: Han-Wei Wang, Ning Chai, Song Hu, Wei Dou, David Umulis, Lihong V. Wang, Michael Sturek, Robert Lucht, Ji-Xin Cheng

Institutions: Washington University in St. Louis, Purdue University West Lafayette, Indiana University Indianapolis, Indiana University School of Medicine

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

OpenAlex ID: W2129434838

FWCI: 0.678

Cites: 5

Cited by: 1

Related to: 10