Role of Pre-B Cell Receptor Signaling Molecules in B Cell Differentiation and Tumor Suppression
Year: 2005
Type: dissertation
Abstract: In this thesis I aimed to unravel the molecular mechanism involved in the origin of acute \\nlymphoblastic leukemia (ALL). This malignant disease is characterized by oncogenic \\ntransformation of progenitors of the B cell lineage in the bone marrow. To study the \\nbasis of this disease I have used a mouse model: mice lacking the signaling protein \\nSlp65. This is an important transducer of signals at the precursor (pre)-B cell stage, \\nwhich reflects a crucial checkpoint for proliferation and differentiation in the bone \\nmarrow. Although Slp65-deficient mice do not show increased sizes of any B-lineage \\nsubpopulation in the bone marrow, a substantial portion of mice develop ALL. To \\nunderstand why these Slp65-deficient cells are prone to oncogenic transformation, \\nknowledge on the function of Slp65 in pre-B cells is required. In the introduction to \\nmy thesis, I first describe the development of B lymphocytes and in particular I focus \\non the pre-B cell stage. We are interested in the functions depending on the signaling \\nprotein Slp65, this involves cellular maturation and differentiation, regulation of V(D)J \\nrecombination and termination of proliferation. \\nThis introduction will help to understand the basis of the mechanisms possibly \\ninvolved in the malignant transformation of Slp65-deficient pre-B cells.
Author: Thị Bình Tạ
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2129579419