The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations
Year: 2013
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations. RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants from among 340,234 participants with 3.99 million person-years of follow-up in eight European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the Phenol-Explorer, the U.K. Food Standards Agency, and the U.S. Department of Agriculture databases. Hazard ratios (HRs) from country-specific Prentice-weighted Cox regression models were pooled using random-effects meta-analysis. RESULTS: In multivariable models, a trend for an inverse association between total flavonoid intake and type 2 diabetes was observed (HR for the highest vs. the lowest quintile, 0.90 [95% CI 0.77-1.04]; P value trend = 0.040), but not with lignans (HR 0.88 [95% CI 0.72-1.07]; P value trend = 0.119). Among flavonoid subclasses, flavonols (HR 0.81 [95% CI 0.69-0.95]; P value trend = 0.020) and flavanols (HR 0.82 [95% CI 0.68-0.99]; P value trend = 0.012), including flavan-3-ol monomers (HR 0.73 [95% CI 0.57-0.93]; P value trend = 0.029), were associated with a significantly reduced hazard of diabetes. CONCLUSIONS: Prospective findings in this large European cohort demonstrate inverse associations between flavonoids, particularly flavanols and flavonols, and incident type 2 diabetes. This suggests a potential protective role of eating a diet rich in flavonoids, a dietary pattern based on plant-based foods, in the prevention of type 2 diabetes.
Source: Diabetes Care
DOI: 10.2337/dc13-0877
Authors: Raul Zamora-Ros, Nita G. Forouhi, Stephen J. Sharp, Carlos A. González, Brian Buijsse, Marcela Guevara, Yvonne T. van der Schouw, Pilar Amiano, Heiner Boeing, Lea Bredsdorff, Françoise Clavel-Chapelon, Guy Fagherazzi, Edith J. Feskens, Paul W. Franks, Sara Grioni, Verena Katzke, Timothy J. Key, Kay-Tee Khaw, Tilman Kühn, Giovanna Masala, Amalia Mattiello, Esther Molina-Montes, Peter M. Nilsson, Kim Overvad, Florence Perquier, J. Ramón Quirós, Isabelle Romieu, Carlotta Sacerdote, Augustin Scalbert, Matthias Schulze, Nadia Slimani, Annemieke M.W. Spijkerman, Anne Tjonneland, Maria Jose Tormo, Rosario Tumino, Daphne L. van der A, Claudia Langenberg, Elio Riboli, Nicholas J. Wareham
Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, MRC Epidemiology Unit, Medical Research Council, German Institute of Human Nutrition, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University Medical Center Utrecht, Biogipuzkoa Health Research Institute, Technical University of Denmark, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Wageningen University & Research, Lund University, Skåne University Hospital, Fondazione IRCCS Istituto Nazionale dei Tumori, German Cancer Research Center, University of Oxford, University of Cambridge, Federico II University Hospital, University of Naples Federico II, Andalusian School of Public Health, Aarhus University, Gobierno del Principado de Asturias, Centre international de recherche sur le cancer, Italian institute for Genomic Medicine, National Institute for Public Health and the Environment, Danish Cancer Society, Universidad de Murcia, Azienda Usl 8 Arezzo, Imperial College London
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2129583955