Work

Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM197Differs Depending on the Serotype of the Attached Polysaccharide

Year: 2003

Type: article

Abstract: The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM(197). Utilizing antigen-processing cells and a CRM(197)-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM(197). Unconjugated CRM(197) and serotype conjugates 14 and 18C were processed more efficiently.

Source: Infection and Immunity

DOI: 10.1128/iai.71.7.4186-4189.2003

Authors: Ethan G. Leonard, David H. Canaday, Clifford V. Harding, John R. Schreiber

Institutions: Rainbow Babies & Children's Hospital, Case Western Reserve University

Language: English

Topic: Pneumonia and Respiratory Infections

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases