Work

Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases

Year: 2014

Type: review

Abstract: Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.b14-00022

Authors: Tomoharu Kuboyama, Chihiro Tohda, Katsuko Komatsu

Institutions: University of Toyama, Institute of Natural Medicine, University of Toyama

Language: English

Topic: Phytochemicals and Medicinal Plants

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministry of Education, Culture, Sports, Science and Technology, Institute of Natural Medicine, University of Toyama, Japan Society for the Promotion of Science