Weight Loss Reduces C- Reactive Protein and Fibrinogen Levels in Obese Women
Year: 2010
Type: article
Study design: Clinical Trial
Abstract: BACKGROUND: obesity is one of the most important risk factors in chronic diseases, like coronary heart disease and diabetes mellitus. It is believed that elevated levels of C- reactive protein (CRP) and fibrinogen are associated with increased cardiovascular risk. We examined the hypothesis that weight loss would reduce plasma CRP and fibrinogen levels in obese women. METHODS: Body weight, fasting glucose, insulin, triglyceride, total cholesterol, high- density lipoprotein cholesterol (HDL-C), low- density lipoprotein cholesterol (LDL-C) and acute phase proteins were measured at baseline and after 12 weeks of weight loss regimen in 29 obese women. RESULTS: Weight, BMI, fasting blood glucose, cholesterol and triglyceride had significant reductions. HDL-C had increased significantly. No significant changes were observed in LDL-C and insulin concentrations. Plasma acute phase proteins levels decreased significantly. CONCLUSION: Weight loss may represent an important intervention to reduce acute phase protein levels, which may mediate its cardioprotective effects in obese women. Keywords: Obesity, weight loss, acute phase proteins, cardiovascular disease, women.
Institution: Tehran University of Medical Sciences
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2129677479