Work

Enantioselective Synthesis of the 5–6–7 Carbocyclic Core of the Gagunin Diterpenoids

Year: 2013

Type: article

Abstract: A catalytic enantioselective double allylic alkylation reaction has been employed in the synthesis of the core of the gagunin diterpenoids. Enantioenriched material was advanced in 11 steps to afford the core of the highly oxygenated target, which includes two all-carbon quaternary stereocenters.

Source: Organic Letters

DOI: 10.1021/ol401514s

Authors: Grant M. Shibuya, John A. Enquist, Brian M. Stoltz

Institution: California Institute of Technology

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: The Synthesis of Bioactive Polycyclic Natural Products