Work

The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae)

Year: 1985

Type: article

Abstract: The ability of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae) to affect the activities of a range of mammalian and microbial aspartic proteinases was examined. The inhibitor appeared to be completely selective in that only the aspartic proteinase A from yeast was inhibited to any significant extent. IA3 thus represents the first example of a totally specific, naturally occurring, aspartic-proteinase inhibitor.

Source: Biochemical Journal

DOI: 10.1042/bj2310777

Authors: T Dreyer, M J Valler, J Kay, P Charlton, B M Dunn

Institutions: Carlsberg Laboratory, University of Florida, Office Of Health Economics, University College London

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Institutes of Health

Award: MECHANISM OF PEPSIN CATALYSIS AND INHIBITION