Year: 2015
Type: article
Abstract: Dysregulated growth factor pathways promote tumor growth in many cancers, but receptor-targeting strategies frequently offer limited benefit despite activation by receptor overexpression or amplification. In contrast, tumors harboring growth factor receptor fusions display exquisite dependence on receptor activity, providing predictive markers for patient response to inform precise oncology treatment. Clin Cancer Res; 21(14); 3105–7. ©2015 AACR. See related article by Di Stefano et al., p. 3307
Source: Clinical Cancer Research
Authors: Manmeet S. Ahluwalia, Jeremy N. Rich
Institution: Cleveland Clinic
Language: English
Topic: HER2/EGFR in Cancer Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1073584004, Targeting Ferritin in Glioblastoma, Metabolism Informs Intertumoral & Intratumoral Heterogeneity, Instructive Cues in Glioblastoma Hierarchies, G6086735254, Targeting Brain Tumor Stem Cells Through Novel Therapeutic Combinations, G727716007, Energy Stress in Brain Tumor Initiating Stem Cells, G8000040458, G826790257
OpenAlex ID: W2129787986