Work

Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit

Year: 2007

Type: article

Abstract: Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00455-07

Authors: Susan J. Schroeder, Gregor Blaha, Peter B. Moore

Institutions: Yale University, Howard Hughes Medical Institute

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: University of Tokyo, National Institutes of Health, National Institute of General Medical Sciences

Awards: Crystallographic Studies of Ribosome Functional Sites, Structural bases of the functions of RNA-protein machines, G9000275824