Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study
Year: 2011
Type: article
Study design: Observational Study
Abstract: Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
Source: Carcinogenesis
Authors: Catherine S. Healey, Shahana Ahmed, Tracy A. O’Mara, Kaltin Ferguson, Diether Lambrechts, Diego A. Garcia-Dios, Ignace Vergote, Frederic Amant, Kimberley Howarth, Maggie Gorman, Shirley Hodgson, Ian Tomlinson, Hannah P. Yang, Jolanta Lissowska, Louise A. Brinton, Stephen Chanock, Montserrat Garcia-Closas, Per Hall, Jianjun Liu, Mitul Shah, Paul D.P. Pharoah, Deborah J. Thompson, Timothy R. Rebbeck, Brian L. Strom, Alison M. Dunning, Douglas F. Easton, Amanda B. Spurdle
Institutions: University of Cambridge, Queensland University of Technology, QIMR Berghofer Medical Research Institute, Vlaams Instituut voor Biotechnologie, Universitair Ziekenhuis Leuven, KU Leuven, Centre for Human Genetics, University of Oxford, St George's, University of London, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, The Maria Sklodowska-Curie National Research Institute of Oncology, Karolinska Institutet, Agency for Science, Technology and Research, Genome Institute of Singapore, Abramson Cancer Center, University of Pennsylvania
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: G1161123863, G1667396066, G1677811041, G1791794685, G2349740481, G236237718, G2453522775, Genetic and Environmental Risk factors for Endometrial Cancer, G2694076841, G305122384, G332802061, MOLECULAR SUSCEPTIBILITY TO HORMONE INDUCED CANCER, G4098640521, G4197410787, G4642945987, G5104521595, G5865683244, G5950516432, G6208597191, G6279653796, G6283257732, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., G7009610138, G7242219286, G7383316951, G8538723892
OpenAlex ID: W2129881169