Gene-protein correlation in single cells
Year: 2011
Type: article
Abstract: We present a novel methodology combining traditional fluorescent in situ hybridization with an in situ protein detection technology called proximity ligation assay. This method has potential to perform a detailed analysis of the relationship between gene status and corresponding protein expression in cells and tissues. We demonstrate that the fluorescent in situ gene protein assay methodology is capable of resolving gene and protein patterns simultaneously on a cell-by-cell basis.
Source: Neuro-Oncology
Institutions: Northwestern University, Barrow Neurological Institute, University of Freiburg, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, University Medical Center Freiburg, University of Alabama at Birmingham, Stanford Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, UAB Medicine, The Ohio State University, Stanford University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2129912800