Work

Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images

Year: 2004

Type: article

Abstract: We have previously reported a comparison between edge-corrected near-infrared optical mammograms and those that have undergone a further image-processing step based on a spatial second derivative. In this work, we go a step further by combining the second-derivative images from four wavelengths (690, 750, 788, and 856 nm) to obtain oxygenation-index images. While the spatial second derivative improves contrast and allows for visibility of fine structures in the images, thereby improving the sensitivity to tumor detection, additional information is needed to avoid false-positive results. The oxygenation-index images are introduced to address this issue. Oxygenation information may help discriminate benign from malignant breast lesions, thereby effectively complementing single-wavelength optical mammograms that display optically dense regions within the breast with high sensitivity.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.1805552

Authors: Erica L. Heffer, Vivian E. Pera, Oliver Schütz, Horst Siebold, Sergio Fantini

Institutions: Tufts University, Massachusetts Institute of Technology, Siemens (Germany)

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, National Cancer Institute