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Inside Cover: Identification of a Novel Protein Synthesis Inhibitor Active against Gram‐Positive Bacteria (ChemBioChem 4/2012)

Year: 2012

Type: article

Abstract: The inside cover picture shows the inhibition of ribosomal protein synthesis in Staphylococcus aureus by the benzothiazolium salt, ABTZ-1. This antibacterial, which inhibits the growth of multidrug-resistant Gram-positive bacteria, prevents the incorporation of radiolabeled methionine into S. aureus protein. Strains resistant to ABTZ-1 also display cross-resistance to fusidic acid and streptogramins. For more information on the discovery and characterization of ABTZ-1 by P. J. Hergenrother et al., see p. 574 ff.

Source: ChemBioChem

DOI: 10.1002/cbic.201290009

Authors: Nora R. Eibergen, Isak Im, Nisha Y. Patel, Paul J. Hergenrother

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2130036552

FWCI: 0.129

Cites:

Cited by: 1

Related to: 10