Year: 2014
Type: review
Abstract: Ca(2+) release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled Ca(2+) influx into cells is store-operated Ca(2+) entry (SOCE), which is activated by the reduction of Ca(2+) concentration in the lumen of endoplasmic or sarcoplasmic reticulum (ER/SR). Although SOCE is pronounced in non-excitable cells, accumulating evidences highlight its presence and important roles in skeletal muscle and heart. Recent discovery of STIM proteins as ER/SR Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming unit expedited the mechanistic understanding of this pathway. This review focuses on current advances of SOCE components, regulation and physiologic and pathophysiologic roles in muscles. The specific property and the dysfunction of this pathway in muscle diseases, and new directions for future research in this rapidly growing field are discussed.
Source: BMB Reports
Authors: Zui Pan, Marco Brotto, Jianjie Ma
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $550
Awards: TRIC, a Novel Modulator of Intracellular Ca Homeostasis, G1485731988, G2534914896, G274416796, OSTEOCYTE REGULATION OF BONE/MUSCLE WITH AGING, MG53-mediated membrane repair in muscle physiology and disease, G5965369171, Ca Sparks in Muscle Aging and Dystrophy, G6346784185, Modulation of MG53 Function in Cardiac Membrane Repair, G9000105815, G9000270380
OpenAlex ID: W2130108942