Work

Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer

Year: 2006

Type: review

Abstract: The microenvironment influences gene expression so that the behavior of a cell is largely determined by its interactions with the extracellular matrix, neighboring cells, and soluble local and systemic cues. We describe the essential roles of context and organ structure in directing mammary gland development and differentiated function and in determining the response to oncogenic insults, including mutations. We expand on the concept of "dynamic reciprocity" to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music.

Source: Annual Review of Cell and Developmental Biology

DOI: 10.1146/annurev.cellbio.22.010305.104315

Authors: Celeste M. Nelson, Mina J. Bissell

Institution: Lawrence Berkeley National Laboratory

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G2343554808, Definition of Microenvironment in Breast Cancer, Role of Metalloproteinases in Mammary Gland Remodeling, Definition of the Microenvironment in Breast Cancer