Mucosal Escherichia coli Bactericidal Activity and Immune Mediators Are Associated With HIV-1 Seroconversion in Women Participating in the HPTN 035 Trial
Year: 2012
Type: article
Abstract: The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.
Authors: C. S. Dezzutti, B. A. Richardson, J. M. Marrazzo, J. Tugetman, G. Ramjee, T. Taha, Z. M. Chirenje, S. S. Abdool Karim, S. L. Hillier, B. C. Herold, on behalf of the MTN Biomedical Sciences Working Group and the HPTN 035 Protocol Team
Institutions: University of Pittsburgh, Magee-Womens Research Institute, University of Washington, Fred Hutch Cancer Center, Albert Einstein College of Medicine, Yeshiva University, South African Medical Research Council, Johns Hopkins University, University of Zimbabwe, Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2130230960