Work

CXCL8 and Its Cognate Receptors in Melanoma Progression and Metastasis

Year: 2009

Type: review

Abstract: The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of CXCL8 and its receptors in melanoma progression and metastasis.

Source: Future Oncology

DOI: 10.2217/fon.09.128

Authors: Seema Singh, Ajay P Singh, Bhawna Sharma, Laurie B Owen, Rakesh K Singh

Institutions: University of South Alabama, University of Nebraska Medical Center, Nebraska Medical Center

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute