Year: 2009
Type: article
Abstract: The membrane and soluble guanylyl cyclases (sGCs) are key families of enzymes that produce the second messenger cGMP.Although both families recognize different ligands and have therefore different N-terminal input domains, they do have similar C-terminal output domains containing a coiled-coil domain and a guanylyl cyclase catalytic domain.We present here our latest structure-function studies on both the sGC and membrane guanylyl cyclases in an effort to enhance our molecular understanding of these receptors to delineate their similarities and differences.Our studies include a new 2.15 Å crystal structure of part of sGC and mutagenesis studies of these families of guanylyl cyclases thereby providing new insights into the structure, activation, and regulation of these receptors.
Source: BMC Pharmacology
Authors: Focco van den Akker, Xiaolei Ma, Faye Martin, Priyaranjan Pattanaik, Pius Padayatti, Matthew Warman, Annie Beuve
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2130936877