Work

Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine

Year: 1989

Type: article

Abstract: Inhibition of DNA synthesis by ara-sangivamycin was antagonized by adenosine. The 50% inhibitory concentrations increased 1.6- to 32-fold in the presence of 1.0 to 50 microM adenosine, respectively. In contrast, the inhibition of human cytomegalovirus replication by ara-sangivamycin was not antagonized by as much as 50 microM adenosine. This suggests that different enzymes were responsible for the phosphorylation of ara-sangivamycin in uninfected and infected cells.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.33.9.1606

Authors: G M Birch, S H Krawczyk, L B Townsend, J C Drach

Institution: University of Michigan

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases