Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses.
Year: 1988
Type: article
Abstract: ARASITIC, bacterial, and viral infections and neoplastic disease profoundly affect host metabolism, disrupting normal homeostatic mechanisms both locally and systemically. A large body of research has documented that many of the observed biological responses to invasive stimuli are mediated by host-secreted cytokines, in particular, the secretory products of activated macrophages. One such cytokine, cachectin/tumor necrosis factor (TNF), ~ has emerged as a particularly important mediator of inflammatory responses. Among its pleiotropic effects, cachectin/TNF has been shown to play a major endocrine role in the pathogenesis of gram-negative endotoxic shock (14, 118) and to induce catabolic responses which could contribute to the profound wasting (cachexia) associated with many chronic diseases (24, 83, 104, 121). It has been implicated in a variety of disease
Source: The Journal of Cell Biology
Institution: Rockefeller University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2131115069