Work

Cytokines expression profiling as a window into hypoxia SH-SY5Y cells treated with N-butyl extract of Potentilla anserina L.

Year: 2013

Type: article

Abstract: Potentilla anserina L. is the root of Chinese cinquefoil herb of the Rosaceae family, and its ethanol extract improves the immunity and exhibits anti-fatigue and anti-hypoxia properties. This study aimed to explore the cytokines expression profiling and the effect of n-butanol extract of P. anserina L. (NP) on the hypoxia cells. The subjects were divided into three groups: control, hypoxia, and intervention (the group treated with the n-butyl extract of P. anserina L. under the condition of hypobaric hypoxia) groups. The results of the experiment showed that NP could down-regulate the expression of the proinflammatory cytokines of hypoxia SH-SY5Y cells and meantime up-regulate the expression of inhibitive cytokines of immune reaction. The cytokines expression profiling can be deduced as a window into hypoxia SH-SY5Y cells, and n-butyl extract of P. anserina L. can significantly protect the cell against the hypoxia induced damage set up in vitro by sodium dithionite. Key words: Hypoxia, inflammatory cytokines, Potentilla anserina L., sodium dithionite.

Source: African Journal of Pharmacy and Pharmacology

DOI: 10.5897/ajpp12.523

Author: Hong-Sheng Gao

Institutions: Logistics University of People's Armed Police Force, Chinese People's Armed Police Force

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation