Year: 2010
Type: article
Abstract: categorized into low grade and high grade.Two-sided non-parametric statistical analyses were performed using the SAS v. 9.3 (SAS Institute, Cary, NC).Results: Expression of KOC, p16, pVHL and Ki67 was significantly different between low and high grade tumor categories.No significant difference was observed for CD117.High grade tumors showed greater expression of Ki-67 (OR=13.85,95% CI 3.34-57.47,p=0.0003), p16 (OR=3.52,95% 1.75-7.11,p=0.0004) and KOC (OR=4.24,95% CI 1.88-9.56,p=0.0005) while pVHL expression was less in high grade tumors (OR=0.3195% CI 0.12-0.84,p=.022).We detected a statistically significant probability of joint overexpression of three of the biomarkers [p16 and KOC and Ki_67] in small cell carcinoma relative to atypical carcinoids (OR=2.53.95% CI 1.24-5.17,p=.011).Conclusions: Findings from this pilot project suggest that Ki-67, KOC and p16 are an effective antibody panel in differentiating high grade neuroendocrine carcinoma from low/intermediate grade neuroendocrine carcinoma.
Source: Clinical Medicine & Research
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2131167363