Year: 2004
Type: review
Abstract: Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the gonadotrope cell and act on the gonad in a sequential and synergistic manner to initiate sexual maturation and maintain cyclic reproductive function. The synthesis and secretion of LH and FSH are regulated mainly by the pulsatile release of the hypothalamic decapeptide hormone gonadotropin-releasing hormone (GnRH). The control of differential LH and FSH synthesis and secretion is complex and involves the interplay between the gonads, hypothalamus and pituitary. In this review, the transcriptional regulation of the gonadotropin subunit genes is discussed in a physiologic setting, and we aimed to examine the mechanisms that drive those changes.
DOI: 10.1677/jme.1.01600
Institution: University of Virginia
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION, G1871647096, REGULATION OF FSHB GENE TRANSCRIPTION IN FEMALE RATS, G4315855773, G5211450561, PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION, G6406654720, Clinical and Basic Studies in Polycystic Ovarian Syndrome, G9000252454, G968666980
OpenAlex ID: W2131226468