Work

Polymeric Core–Shell Assemblies Mediated by Host–Guest Interactions: Versatile Nanocarriers for Drug Delivery

Year: 2008

Type: article

Abstract: First class delivery: Core–shell structured nanoassemblies could be constructed from a hydrophilic–hydrophilic block copolymer with one block containing β-cyclodextrin in the presence of hydrophobic guest compounds (see picture). The polymer can host various guest molecules, while the difference in sensitivity can be utilized to regulate release rate. By selecting appropriate guests, polyion complex (PIC) micelles could also be assembled.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200804135

Authors: Jianxiang Zhang, Peter X. Ma

Institution: University of Michigan

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Dental and Craniofacial Research