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Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles

Year: 2014

Type: article

Abstract: We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.

Source: Chemical Communications

DOI: 10.1039/c3cc49453e

Authors: Andrew G. Cheetham, Yu-Chuan Ou, Pengcheng Zhang, Honggang Cui

Institution: Johns Hopkins University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute