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A Multi-Cohort Study of Polymorphisms in the GH/IGF Axis and Physical Capability: The HALCyon Programme

Year: 2012
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Low muscle mass and function have been associated with poorer indicators of physical capability in older people, which are in-turn associated with increased mortality rates. The growth hormone/insulin-like growth factor (GH/IGF) axis is involved in muscle function and genetic variants in genes in the axis may influence measures of physical capability. METHODS: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women from seven UK cohorts aged between 52 and 90 years old were genotyped for six polymorphisms: rs35767 (IGF1), rs7127900 (IGF2), rs2854744 (IGFBP3), rs2943641 (IRS1), rs2665802 (GH1) and the exon-3 deletion of GHR. The polymorphisms have previously been robustly associated with age-related traits or are potentially functional. Meta-analysis was used to pool within-study genotypic effects of the associations between the polymorphisms and four measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance. RESULTS: Few important associations were observed among the several tests. We found evidence that rs2665802 in GH1 was associated with inability to balance for 5 s (pooled odds ratio per minor allele = 0.90, 95% CI: 0.82-0.98, p-value = 0.01, n = 10,748), after adjusting for age and sex. We found no evidence for other associations between the polymorphisms and physical capability traits. CONCLUSION: Our findings do not provide evidence for a substantial influence of these common polymorphisms in the GH/IGF axis on objectively measured physical capability levels in older adults.
Source: PLoS ONE
DOI: 10.1371/journal.pone.0029883
Authors: Tamuno Alfred, Yoav Ben-Shlomo, Rachel Cooper, Rebecca Hardy, Cyrus Cooper, Ian J. Deary, Tom R. Gaunt, David Gunnell, Sarah E. Harris, Meena Kumari, Richard M. Martin, Avan Aihie Sayer, John M. Starr, Diana Kuh, Ian N. M. Day, the HALCyon study team
Institutions: University of Bristol, MRC Unit for Lifelong Health and Ageing, University College London, University of Oxford, MRC Lifecourse Epidemiology Unit, University of Southampton, University of Edinburgh, Southampton General Hospital
Language: English
Subfield: Genetics
Open Access status: gold
Estimated APC paid: $2,382
Funders: Wellcome Trust, National Institute for Health and Care Research, British Heart Foundation, University of Southampton, University College London, University of Edinburgh, University of Bristol, Versus Arthritis, Centre for Cognitive Ageing and Cognitive Epidemiology, National Institutes of Health, Directorate for Biological Sciences, Medical Research Council, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, World Cancer Research Fund, National Institute on Aging
Awards: G1093300281, HALCyon Healthy Ageing across the Life Course, G2507151542, G2719016821, G2928833717, G3747358395, G3812491970, G443238052, G4641403149, G4746977625, G4856618060, G4942547004, G4950536974, NIHR Senior Investigator Award, G538581767, G5503240538, G6172210748, A genome-wide association study of non-pathological cognitive ageing, G7572990571, G7584390538
OpenAlex ID: W2131599113
FWCI: 1.239
Cites: 85
Cited by: 12
Related to: 10