Work

Promotion of Dendritic Growth by CPG15, an Activity-Induced Signaling Molecule

Year: 1998

Type: article

Abstract: Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.

Source: Science

DOI: 10.1126/science.281.5384.1863

Authors: Elly Nedivi, Gang-Yi Wu, Hollis T. Cline

Institution: Cold Spring Harbor Laboratory

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funder: National Eye Institute

Award: MOLECULAR GENETIC ANALYSIS OF CORTICAL PLASTICITY