Work

Copper‐Catalyzed Trifluoromethylation of Unactivated Olefins

Year: 2011

Type: article

Abstract: Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201104053

Authors: Andrew T. Parsons, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources